Baseline white matter microstructural integrity is not related to cognitive decline after 5 years: The RUN DMC study
نویسندگان
چکیده
•DTI can provide information on microstructural white matter integrity.•White matter microstructural integrity is not related to cognitive decline in SVD.•These results are in contrast with cross-sectional findings.•Other factors than white matter microstructural damage underlie this cognitive decline.
منابع مشابه
Causes and consequences of cerebral small vessel disease. The RUN DMC study: a prospective cohort study. Study rationale and protocol
BACKGROUND Cerebral small vessel disease (SVD) is a frequent finding on CT and MRI scans of elderly people and is related to vascular risk factors and cognitive and motor impairment, ultimately leading to dementia or parkinsonism in some. In general, the relations are weak, and not all subjects with SVD become demented or get parkinsonism. This might be explained by the diversity of underlying ...
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